Peptide YY

peptide YY Symbol(s): PYY Locus: 17 q21.1 EC number [1] EntrezGene 5697 OMIM 600781 RefSeq NM_004160 UniProt P10082 Pancreatic Peptide YY3-36 is a peptide produced in the small intestine and colon that reduces appetite in response to feeding. Contents 1 Descripción 2 Relevance to obesity 3 Referencias 4 External links Description Peptide YY3-36 (PYY) is a linear polypeptide consisting of 36 amino acids with structural homology to NPY and pancreatic polypeptide. PYY exerts its action through neuropeptide Y receptors, inhibits gastric motility and increases water and electrolyte absorption in the colon.[1] It is secreted by the gut in response to a meal, and has been shown to reduce appetite. Relevance to obesity Leptin also reduces appetite in response to feeding, but obese people develop a resistence to leptin. En contraste, obese people secrete less PYY than normal people do, and in response to added PYY, they reduce their food intake.[2] References ↑ Liu C, Aloia T, Adrian T, Newton T, Bilchik A, Zinner M, Ashley S, McFadden D (1996). Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders.. Am Surg 62 (3): 232-6. PMID 8607584. ↑ Batterham RL et al (Septiembre 4, 2003). Inhibition of food intake in obese subjects by peptide YY3-36. New England Journal of Medicine 349 (10): 926-928. PMID 12954742. External links MeSH Peptide+YY This protein-related article is a stub. Puedes ayudar a Wikipedia expandiéndola. Esta página utiliza contenido con licencia Creative Commons de Wikipedia (ver autores).