Kleine-Levin syndrome

· Kleine-Levin syndrome ICD-10 G478 ICD-9 327.13 OMIM 148840 EnfermedadesDB 29520 Medline Plus [1] eMedicina / Malla {{{Número de malla}}} Kleine-Levin Syndrome, or KLS, is a rare disorder characterized by the need for excessive amounts of sleep (hipersomnia), (p. ej.. hasta 20 hours a day); excessive food intake (compulsive hyperphagia); and an abnormally uninhibited sexual drive. Adolescent males are the predominant victims of the disorder. Contenido 1 Presentación 2 Causas 3 Tratamiento 4 Eponym 5 Referencias 6 External links Presentation Individual sufferers may often become irritable, lethargic, and/or apathetic. KLS patients may appear disoriented and report hallucinations. Symptoms are cyclical; with days to weeks (even up to months) of suffering interspersed by weeks or months (even up to years) symptom-free. Although resolution of the disorder may occur for some in later life, this is not universal. Causes While some researchers speculate of a hereditary predisposition; others believe the condition may be the result of an autoimmune disorder.[1] Both proposals need not be mutually exclusive with the result being a malfunction of the portion of the brain that helps to regulate functions such as sleep, appetite, and body temperature (hypothalamus). Similarities between KLS and Klüver-Bucy syndrome (another rare condition characterized by hyperphagia, hipersexualidad, and emotional blunting) may warrant further attention. Treatment There is no definitive treatment for Kleine-Levin syndrome. estimulantes, including amphetamines, metilfenidato, imipramine and modafinil, administered orally, are used to treat sleepiness. Because of similarities between Kleine-Levin syndrome and certain mood disorders, lithium and carbamazepine may be prescribed. Responses to treatment have often been limited. This disorder needs to be differentiated from cyclic re-occurrence of sleepiness during the premenstrual period in teenage girls that may be controlled with hormonal contraception. [2] Eponym It is named for Willi Kleine and Max Levin.[3][4][5] Referencias ↑ http://med.stanford.edu/school/Psychiatry/narcolepsy/KLS.html ↑ http://www.ninds.nih.gov/disorders/kleine_levin/kleine_levin.htm ↑ Who Named It synd/1398 ↑ W. Kleine. Periodische Schlafsucht. Monatsschrift für Psychiatrie und Neurologie, 1925, 57: 285-320. ↑ M.. Levin. Periodic somnolence and morbid hunger: A new syndrome. Cerebro, Oxford, 1936, 59: 494-504. External links The KLS Foundation kleine_levin at NINDS v·d·e Nervous system disorders, primarily CNS (G04–G47, 323–349) Inflammation Brain Encephalitis (Viral encephalitis, Herpesviral encephalitis) · Cavernous sinus thrombosis · Brain abscess (Amoebic) Spinal cord Myelitis: Poliomyelitis · Demyelinating disease (Transverse myelitis) · Tropical spastic paraparesis · Epidural abscess Both/either Encephalomyelitis (Acute disseminated) Meningoencephalitis Brain/ encephalopathy Degenerative Extrapyramidal and movement disorders Basal ganglia disease: Parkinsonismo (PD, Postencephalitic, NMS) · PKAN · Tauopathy (PSP) · Striatonigral degeneration · Hemiballismus · HD · OA Dyskinesia: Dystonia (Status dystonicus, Spasmodic torticollis, Meige's, Blepharospasm) · Athetosis, Chorea (Choreoathetosis) · Myoclonus (Myoclonic epilepsy) · Akathesia Tremor (Essential tremor, Intention tremor) · Restless legs · Stiff person Dementia Tauopathy: Alzheimer's (Early-onset) Primary progressive aphasia · Frontotemporal dementia/Frontotemporal lobar degeneration (Pick's, Dementia with Lewy bodies) Multi-infarct dementia Mitochondrial disease Leigh's disease Demyelinating autoimmune (Esclerosis múltiple, Neuromyelitis optica, Schilder's disease) · hereditary (Adrenoleukodystrophy, Alexander, Canavan, Krabbe, ML, PMD, VWM, MFC, CAMFAK syndrome) · Central pontine myelinolysis · Marchiafava-Bignami disease · Alpers' disease Episodic/ paroxysmal Seizure/epilepsy Focal · Generalised · Status epilepticus · Myoclonic epilepsy Headache Migraine (Familial hemiplegic) · Cluster · Tension Cerebrovascular TIA (Amaurosis fugax, Transient global amnesia Acute aphasia) Stroke (ACM, ACA, PCA, Foville's, Millard-Gubler, Lateral medullary, Weber's, Lacunar stroke) Sleep disorders Insomnia · Hypersomnia · Sleep apnea (Obstructive, Ondine's curse) · Narcolepsy · Cataplexy · Kleine-Levin · Circadian rhythm sleep disorder (Advanced sleep phase disorder, Delayed sleep phase disorder, Non-24-hour sleep-wake disorder, Jet lag) CSF Intracranial hypertension (Hydrocephalus/NPH, Idiopathic intracranial hypertension) · Cerebral edema · Intracranial hypotension Other Brain herniation · Reye's · Hepatic encephalopathy · Toxic encephalopathy Spinal cord/ myelopathy Syringomyelia · Syringobulbia · Morvan's syndrome · Vascular myelopathy (Foix-Alajouanine syndrome) · Spinal cord compression Both/either Degenerative SA Friedreich's ataxia · Ataxia telangiectasia MND UMN only: PLS · PP · HSP LMN only: Distal hereditary motor neuropathies · Spinal muscular atrophies (SMA, SMAX1, SMAX2, DSMA1, SMA-PCH, SMA-LED) · PMA · PBP (Fazio-Londe, Infantile progressive bulbar palsy) both: ESCLEROSIS LATERAL AMIOTRÓFICA {| clase="navbox plegable nowraplinks" estilo="margen:auto; " [. v]·[. d]·[. e] M: CNS anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr proc, droga (N1A/2AB/C/3/4/7A/B/C/D) |} Esta página utiliza contenido con licencia Creative Commons de Wikipedia (ver autores).