Aromatic L-amino acid decarboxylase

DOPA decarboxylase (aromatic L-amino acid decarboxylase) Symbol(s): DDC Locus: 7 p11 EC number 4.1.1.28 EntrezGene 1644 OMIM 107930 RefSeq NM_000790 UniProt P20711 Aromatic L-amino acid decarboxylase (EC 4.1.1.28, synonyms: DOPA decarboxylase, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) is a lyase enzyme. Contents 1 Reacciones 2 As a rate limiting step 3 Genética 4 Ver también 5 Referencia 6 External links Reactions It catalyzes several different decarboxylation reactions: L-DOPA to dopamine - a neurotransmitter 5-HTP to serotonin (5-HT) - also a neurotransmitter tryptophan to tryptamine - a precursor to many alkaloids found in plants and animals The enzyme uses pyridoxal phosphate as a cofactor. As a rate limiting step In normal dopamine and serotonin (5-HT) neurotransmitter synthesis, AAAD is not the rate-limiting step in either reaction. Sin embargo, AAAD becomes the rate-limiting step of dopamine synthesis in patients treated with L-DOPA (such as in Parkinson's Disease), and the rate-limiting step of serotonin synthesis in people treated with 5-HTP (such as in mild depression or dysthymia).  AAAD is the rate-limiting enzyme in the formation of biogenic trace amines. dopamine serotonin Genetics The gene encoding the enzyme is located on chromosome 7 in humans.[1] See also Aromatic amino acids Reference ↑ Lisa J. Scherer, Juan D.. McPherson, Juan J. Wasmuth and J. Lawrence Marsh (Junio 1992). Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs. Genomics 13 (2): 469–471. External links MeSH Aromatic-L-Amino-Acid+Decarboxylases }} v·d·e Carbon-carbon lyases (EC 4.1) 4.1.1: Carboxy-lyases Pyruvate decarboxylase -Oxaloacetate decarboxylase - Acetoacetate decarboxylase - Malonyl-CoA decarboxylase - Glutamato descarboxilasa - Ornithine decarboxylase - Lysine decarboxylase - Phosphoribosylaminoimidazole carboxylase - Histidine decarboxylase - Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase - Aromatic L-amino acid decarboxylase - Phosphoenolpyruvate carboxylase - Pyrophosphomevalonate decarboxylase - Uroporphyrinogen III decarboxylase - RuBisCO - Phosphoenolpyruvate carboxykinase - Adenosylmethionine decarboxylase 4.1.2: Aldehyde-lyases Aldolase A/Aldolase B - 2-hydroxyphytanoyl-CoA lyase 4.1.3: Oxo-acid-lyases 3-hydroxy-3-methylglutaryl-CoA lyase v·d·e Amino acid metabolism enzymes phenylalanine→tyrosine→fumarate→TCA Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase tyrosine→dopamine→epinephrine Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase leucine→HMG-CoA (keto) Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase isoleucine/valine→propionyl-CoA Branched-chain alpha-keto acid dehydrogenase complex methionine→cysteine→propionyl-CoA Methionine adenosyltransferase - Adenosylhomocysteinase - (or MTR) - Cystathionine beta synthase - Cystathionine gamma-lyase propionyl-CoA→succinyl-CoA→TCA Propionyl-CoA carboxylase - Methylmalonyl-CoA mutase serine→glycine Serine hydroxymethyltransferase histidine to histamine: Histidine decarboxylase - to glutamate: Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase tryptophan→serotonin→melatonin Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - 5-hydroxyindole-O-methyltransferase asparagine→aspartate→oxaloacetate→TCA Asparaginase/Asparagine synthetase - Aspartate transaminase glutamate Glutaminase - Glutamate decarboxylase lysine→keto Saccharopine dehydrogenase other Tyrosinase This page uses Creative Commons Licensed content from Wikipedia (ver autores).